Publications and Media Highlights

Media highlights

• Fusing biology with the bionic ear | Engineering and Technology Magazine. Heidi Vella 07/07/23  - reports the CINGT clinical trial in the context of innovations in medical bionics
• Channel 9 News, August 2024, 40 years of cochlear implants in Australia
  
• Channel 9 News, June 2022, CINGT clinical trial patient experience
  

Publications

1. Title: Electric Field Focusing Gene Electrotransfer for Cochlear DNA Therapeutics

   Housley, G. D., von Jonquieres, G., Browne, C. J., Crawford, E. N., Klugmann, M., Housley, D. M., Wise, A. K., Fallon, J. B., Enke, Y. L., Gay, R. D., Patrick, J. F., Caproni, L. J., Sherman, D., Marie, C., McMahon, C., McAlpine, D., Birman, C., Alnafjan, F., Abed, A. A., Lovell, N. H., & Pinyon, J. L. Handbook of Electroporation, 2nd Edition, Springer Nature Switzerland AG, pp. 1–25 (2026). doi:10.1007/978-3-319-26779-1_59-2

2. Title: Gene Electrotransfer via Conductivity‑Clamped Electric Field Focusing Pivots Sensori‑Motor DNA Therapeutics: “A Spoonful of Sugar Helps the Medicine Go Down”

   Pinyon, J. L., Browne, C. J., Crawford, E. N., Duxbury, M., von Jonquieres, G., Al Abed, A., Lovell, N. H., Klugmann, M., Wise, A. K., Fallon, J. B., Shepherd, R. K., Birman, C. S., Lai, W., McAlpine, D., McMahon, C., Carter, P. M., Enke, Y. L., Patrick, J. F., Schilder, A. G. M., Marie, C., Scherman, D., & Housley, G. D. Advanced Science, 2024 (August issue). DOI: 10.1002/advs.202470180

   
3. Title: Neurotrophin Gene Augmentation by Electrotransfer to Improve Cochlear Implant Hearing Outcomes

   Pinyon, J. L., von Jonquieres, G., Crawford, E. N., Duxbury, M., Al Abed, A., Lovell, N. H., Klugmann, M., Wise, A. K., Fallon, J. B., Shepherd, R. K., Birman, C. S., Lai, W., McAlpine, D., McMahon, C., Carter, P. M., Enke, Y. L., Patrick, J. F., Schilder, A. G. M., Marie, C., Scherman, D., & Housley, G. D. Hearing Research, 380:137–149 (2019). doi:10.1016/j.heares.2019.06.002

4. Title: Dual-Plasmid Bionic Array-Directed Gene Electrotransfer in HEK293 Cells and Cochlear Mesenchymal Cells Probes Transgene Expression and Cell Fate

   Pinyon, J. L., Klugmann, M., Lovell, N. H., & Housley, G. D. Human Gene Therapy, 30(2). Published online 8 Feb 2019. https://doi.org/10.1089/hum.2018.062

5. Title: Cochlear Implant Close-Field Electroporation

   Housley, G. D., Browne, C. J., Crawford, E. N., Klugmann, M., Lovell, N. H., & Pinyon, J. L. In: Miklavcic, D. (ed.) Handbook of Electroporation. Springer, Cham (2016). pp. 1–20. DOI: 10.1007/978-3-319-26779-1_59-1

6. Title: Mapping of Bionic Array Electric Field Focusing in Plasmid DNA-Based Gene Electrotransfer

   Browne, C. J., Pinyon, J. L., Housley, D. M., Crawford, E. N., Lovell, N. H., Klugmann, M., & Housley, G. D. Gene Therapy, 23:369–379 (2016). Doi:10.1038/gt.2016.8

7. Title: Improving the Cochlear Implant — Interview with Gary Housley

   Housley, G. (interviewee) The Naked Scientists, 28 April 2014. (Audio available via The Naked Scientists website.)

8. Title: Gene Therapy Boosts the Bionic Ear

   Shepherd, R. K., & Wise, A. K. Science Translational Medicine, 23 April 2014, 233fs17.

9. Title: Close-Field Electroporation Gene Delivery Using the Cochlear Implant Electrode Array Enhances the Bionic Ear

   Pinyon, J. L., Tadros, S. F., Froud, K. E., Wong, A. C. Y., Tompson, I. T., Crawford, E. N., Ko, M., Morris, R., Klugmann, M., & Housley, G. D. Science Translational Medicine, 23 April 2014, 233ra54. DOI: 10.1126/scitranslmed.3008177

   

Conflict of Interest

The development of Bionic array Directed Gene Electrotransfer (BaDGE® - copyright holder UNSW Sydney through assignee New South Innovations Pty Ltd) includes a portfolio of patent filings associated with this research. These include:

1. US Patent: US95133138B2 2017.
   Title: Method of providing agents to the cochlea.
   Inventor: GD Housley.
   Filing status: National Phase Examination – Europe (application no. 10799287.7; filing date 5 July 2010),
   United States (application no. 14/145,673; approved 26th August 2016).
   Assignee: NewSouth Innovations Pty Limited.
2. US Patent: US11013917B2 2021.
   Title: Method and apparatus for close-field electroporation.
   Inventor: GD Housley, M Klugmann, J Pinyon.
   Filing status: Provisional, Australia (application no. 2013902263; filed 21 June 2013).
   Assignee: NewSouth Innovations Pty Limited.
3. US Patent: US11213671B2 2022.
   Title: Electroporation system for controlled localized therapeutics delivery.
   Inventor: GD Housley, NH Lovell.
   Filing status: Australian Provisional Patent filing (application no. 2015902456; filing date 25 June 2015).
   Assignee: NewSouth Innovations Pty Limited.